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Impact of overlapping recruitment on linkage analysis of complex disorders: Simulation studies

โœ Scribed by Davis, Sean ;Nimgaonkar, Vishwajit L.


Book ID
115548480
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
102 KB
Volume
105
Category
Article
ISSN
0148-7299

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โœ Douglas F. Levinson ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 33 KB ๐Ÿ‘ 2 views

The problem of linkage analysis of disorders with multiple possible phenotypes (diagnostic spectrum) is considered. A modification is proposed to Ott's [1994] method of down-weighting the contribution of broader diagnoses by reducing penetrance ratios for affected cases. A "robust weighting" strateg