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Impact of numerical variation in FMS-like tyrosine kinase receptor 3 internal tandem duplications on clinical outcome in normal karyotype acute myelogenous leukemia

✍ Scribed by Gautam Borthakur; Hagop Kantarjian; Keyur P. Patel; Farhad Ravandi; Wei Qiao; Stefan Faderl; Tapan Kadia; Raja Luthra; Sherry Pierce; Jorge E. Cortes

Book ID
112067177
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
813 KB
Volume
118
Category
Article
ISSN
0008-543X

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Internal tandem duplication and Asp835 m
Internal tandem duplication and Asp835 mutations of the FMS-like tyrosine kinase 3 (FLT3) gene in acute promyelocytic leukemia : Correlation with molecular subtypes of PML/RARΞ± and clinical features
✍ Lee-Yung Shih; Ming-Chung Kuo; Der-Cherng Liang; Chein-Fuang Huang; Tung-Liang L πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 122 KB πŸ‘ 2 views

## Abstract ## BACKGROUND The clinical relevance of mutations of the __FMS__‐like tyrosine kinase 3 (__FLT3__) gene in specific cytogenetic subgroups is not clear. The authors examined internal tandem duplication (ITD) and Asp835 mutations of __FLT3__ in patients with acute promyelocytic leukemia