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Impact of nodal ratio on survival in squamous cell carcinoma of the oral cavity

✍ Scribed by Mark G. Shrime; Clement Ma; Patrick J. Gullane; Ralph W. Gilbert; Jonathan C. Irish; Dale H. Brown; David P. Goldstein

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
120 KB
Volume
31
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background

The association between nodal ratio and survival has not been assessed in squamous cell carcinomas of the head and neck.

Methods

This is a population‐based analysis, using the Surveillance, Epidemiology, and End‐Results database, to determine whether nodal ratio impacts survival in patients with oral cavity squamous cell carcinoma.

Results

Between 1988 and 2005, 2955 new diagnoses of N~1~ or N~2~ squamous cell carcinoma of the oral cavity were identified. The mean nodal ratio was 16.9%. Nodal ratio was found to be strongly statistically associated with overall survival in both univariate and multivariate analyses. Patients could be stratified into low‐ (0% to 6%), moderate‐ (6% to 12.5%), and high‐risk (>12.5%) groups based on nodal ratio.

Conclusions

In patients with squamous cell carcinoma of the oral cavity, an increased nodal ratio is a strong predictor of decreased survival. Risk of death can be stratified based on nodal ratio. Β© 2009 Wiley Periodicals, Inc. Head Neck, 2009

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