Impact of myocardial inflammation on cytosolic and mitochondrial creatine kinase activity and expression
✍ Scribed by Linda Ebermann; Cornelia Piper; Uwe Kühl; Karin Klingel; Uwe Schlattner; Nikias Siafarikas; Heinz Zeichhardt; Heinz-Peter Schultheiss; Andrea Dörner
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 389 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0300-8428
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Mitochondrial creatine kinase (MtCK) plays a central role in energy homeostasis within cells that display high and variable rates of ATP turnover. Vertebrate MtCKs exist primarily as octamers but readily dissociate into constituent dimers under a variety of circumstances. MtCK is an ancient protein
Ten-week-old Sprague-Dawley rats were held behind the front legs before and during anesthetic injection of sodium pentobarbital (group 1, 12 rats), or lifted by the base of the tail before and during injection (group 2, 12 rats). Creatine kinase (CK) values were higher (P = 0.004) in group 1 (median