Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis
β Scribed by Christopher T. Harp; Amy E. Lovett-Racke; Michael K. Racke; Elliot M. Frohman; Nancy L. Monson
- Book ID
- 113540641
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 736 KB
- Volume
- 128
- Category
- Article
- ISSN
- 1090-2341
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## Abstract While it is widely accepted that myelin reactive T cells are key players in the immunopathogenesis of multiple sclerosis (MS), the initial triggers that turn on these selfβreactive Tβcells remain to be determined. One mechanism, which is already text book knowledge for a decade, is mole
## Activation of specific T cell lines by the antigens avidin and myelin basic protein in the absence of antigen-presenting cells We have investigated the specific activation by soluble antigen of rat or mouse longterm T helper cell lines using antigen-presenting cell (APC)-free culture conditions