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Impact of molecular surface characteristics on the reversed-phase retention behaviour of synthetic dyes

✍ Scribed by Tibor Cserháti; Gyula Oros

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
65 KB
Volume
13
Category
Article
ISSN
0269-3879

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✦ Synopsis

The lipophilicity and specific hydrophobic surface area of 42 synthetic dyes were determined on reversed-phase alumina layers using water-methanol mixtures as eluents, and their relationship with the molecular surface characteristics was elucidated by principal component analysis followed by a two-dimensional nonlinear map and cluster analysis. Four dyes remained on the origin in each eluent system. Except for two dyes, the majority showed regular retention behaviour with their retention decreasing steadily with increasing concentration of methanol in the mobile phase. Calculations indicated that both hydrophobicity parameters decrease with increasing polar surface area of the molecules.

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Effect of conformational changes on the
Effect of conformational changes on the reversed-phase chromatographic retention of polyoxyethylenes: quantitative interpretation based on a retention model in combination with molecular mechanics
✍ Tetsuo Okada 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 782 KB

The reversed-phase chromatographic retention of compounds having polyoayethylene (POE) as a part of the structure is known to be affected by conformational changes of the POE chains. A modified two-state model, where zig-zag and helii conformers are assumed to be more stable than others, was develop