Impact of incidental magnetization transfer effects on inversion-recovery sequences that use a fast spin-echo readout

✍ Scribed by Simon J.P. Meara; Gareth J. Barker

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 210 KB
• Volume: 58
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.21338

✦ Synopsis

Abstract

Multislice MR images obtained using a fast spin‐echo (FSE) readout are strongly affected by magnetization transfer (MT) effects, which will cause a decrease in the observed longitudinal relaxation times for tissues with a large bound water component. This is pertinent for FSE‐based inversion‐recovery (IR) sequences, as it would be expected to cause a change in the required inversion times. Furthermore, the effect will be greater as the number of slices that are acquired within the repetition time (TR) is increased. A pseudo‐3D IR‐FSE sequence was used to obtain images of a phantom consisting of thermally crosslinked bovine serum albumin. It was found that increasing the number of slabs acquired per TR period led to a decrease in the inversion time that maximally suppressed the signal from the MT phantom; this was not the case for water. This has important consequences for any IR imaging sequence that uses an FSE readout. Magn Reson Med 58:825–829, 2007. © 2007 Wiley‐Liss, Inc.