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Impact of immunophenotype on prognosis of patients with myelodysplastic syndromes. Its value in patients without karyotypic abnormalities

✍ Scribed by Arroyo, Jose Luis; Fernández, Ma Eugenia; Hernández, Jesús Maria; Orfao, Alberto; Miguel, Jesús Fernando San; Cañizo, Maria Consuelo del


Book ID
120503094
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
135 KB
Volume
5
Category
Article
ISSN
1466-4860

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The fragile histidine triad (FHIT) gene plays an important role in anti-cancer and the abnormal methylation of FHIT gene is found in many carcinomas. The epigenetic changes of tumor suppressor genes (TSG) are now recognized as an abnormal mechanism contributing to the development of myelodysplastic