Impact of host and virus genome variability on HCV replication and response to interferon
β Scribed by Schweitzer, Cameron J; Liang, T Jake
- Book ID
- 120975894
- Publisher
- Elsevier
- Year
- 2013
- Tongue
- English
- Weight
- 728 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1879-6257
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π SIMILAR VOLUMES
Amino acid (aa) substitutions of core 70 and 91 and in the NS5A (nonstructural protein 5A) interferon sensitivity determining region (ISDR) as well as genetic polymorphisms in the host interleukin-28B (IL28B) locus affect the outcome of interferon (IFN)-based therapies for patients with chronic hepa
In patients with chronic hepatitis C, the influence of the genetic heterogeneity of the hepatitis C virus (HCV) on the progression of liver disease and on the responsiveness to interferon therapy is a matter of controversy. In this study we evaluated the genetic complexity of HCV by singlestrand con