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Impact of BRCA mutations on female fertility and offspring sex ratio

✍ Scribed by Roxana Moslehi; Ranjana Singh; Lawrence Lessner; Jan M. Friedman


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
77 KB
Volume
22
Category
Article
ISSN
1042-0533

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## Abstract ## BACKGROUND Overexpression of p53 has been associated with poor survival following breast carcinoma. BRCA1 interacts biochemically with p53 and may also contribute to poor outcome when constitutionally mutated. The joint effect of both abnormalities has not been studied. The primary