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Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells

โœ Scribed by Ingo Walter; Tanja Schwerdtle; Christina Thuy; Jason L. Parsons; Grigory L. Dianov; Andrea Hartwig


Book ID
113567777
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
682 KB
Volume
6
Category
Article
ISSN
1568-7864

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## Abstract Copper is an essential trace element involved, among other functions, in enzymatic antioxidative defense systems. However, nonprotein bound copper ions have been shown to generate reactive oxygen species. To gain insight into the discrepancy between the protective properties of copper o