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Impact of apolipoprotein E ɛ4 (APOE4) on brain activation during working memory in cognitively intact individuals

✍ Scribed by Markov, V; Krug, A; Krach, S; Jansen, A; Stöker, T; Shah, N.J.; Eggermann, T; Zerres, K; Nöthen, M.M.; Treutlein, J; Rietschel, M; Kircher, T

Book ID: 122900787
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 129 KB
Volume: 47
Category: Article
ISSN: 1053-8119
DOI: 10.1016/S1053-8119(09)71709-4

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## Abstract Working memory (WM) dysfunction is a hallmark feature of schizophrenia. Functional imaging studies using WM tasks have documented both prefrontal hypo‐ and hyperactivation in schizophrenia. Schizophrenia is highly heritable, and it is unclear which susceptibility genes modulate WM and i