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IMP dehydrogenase and action of antimetabolites in human cultured blast cells

✍ Scribed by Yasukazu Yamada; Haruko Goto; Masataka Yoshino; Nobuaki Ogasawara

Book ID
119121140
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
472 KB
Volume
1051
Category
Article
ISSN
0167-4889

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Tiazofurin, an anticancer drug which inhibits IMP dehydrogenase, decreases cellular GTP concentration, induces differentiation and down-regulates ras and myc oncogene expression, caused apoptosis of K562 cells in a time-and dose-dependent fashion. Apoptotic cells were detected by (1) flow cytometry,