This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.Content:
Chapter 1 The Immune Response to a Transplanted Organ: An Overview (pages 3โ9): Fadi G. Lakkis
Chapter 2 Antigen Presentation in Transplantation (pages 10โ18): Martin H. Oberbarnscheidt and Fadi G. Lakkis
Chapter 3 The T Cell Response to Transplantation Antigens (pages 19โ37): Didier A. Mandelbrot, Bryna Burrell, Mohamed H. Sayegh and Peter S. Heeger
Chapter 4 The B Cell Response to Transplantation Antigens (pages 38โ53): Roger Sciammas, Anita S. Chong and Robert B. Colvin
Chapter 5 The Innate Response to a Transplanted Organ (pages 54โ61): Daniel R. Goldstein and Laurence A. Turka
Chapter 6 Regulation of the Alloimmune Response (pages 62โ78): Kathryn J. Wood and Terry B. Strom
Chapter 7 Pharmacokinetics (pages 81โ94): Venkateswaran C. Pillai and Raman Venkataramanan
Chapter 8 Therapeutic Drug Monitoring for Immunosuppressive Agents (pages 95โ113): Michael C. Milone and Leslie M. J. Shaw
Chapter 9 Pharmacometrics: Concepts and Applications to Drug Development (pages 114โ132): Mallika Lala and Jogarao V. S. Gobburu
Chapter 10 Pharmacogenomics and Organ Transplantation (pages 133โ145): Gilbert J. Burckart and Richard M. Watanabe
Chapter 11 Study Design/Process of Development: Clinical Studies (pages 146โ159): Richard D. Mamelok
Chapter 12 Corticosteroids (pages 163โ170): Olivia R. Blume, Sarah E. Yost and Bruce Kaplan
Chapter 13 Azathioprine (pages 171โ181): Barry J. Browne
Chapter 14 Pharmacokinetic and Pharmacodynamic Properties of Mycophenolate (pages 182โ196): David Hager, Arjang Djamali and Bruce Kaplan
Chapter 15 Cyclosporine: Molecular Action to Clinical Therapeutics (pages 197โ223): Bradford Strijack and Paul A. Keown
Chapter 16 Tacrolimus (pages 224โ240): William E. Fitzsimmons
Chapter 17 Inhibitors of Mammalian Target of Rapamycin (pages 241โ272): Barry D. Kahan
Chapter 18 Inhibitors Targeting JAK3 (pages 273โ289): Gary Chan and Paul S. Changelian
Chapter 19 Cyclophosphamide (pages 290โ295): John J. Curtis
Chapter 20 Application of Antisense Technology in Medicine (pages 296โ315): Beata Mierzejewska and Stanislaw M. Stepkowski
Chapter 21 The Role of Ganciclovir in Transplantation (pages 316โ329): Lyndsey J. Bowman and Daniel C. Brennan
Chapter 22 Transplantation Immunotherapy with Antithymocyte Globulin (ATG) (pages 330โ345): John L. Dzuris, Christian Bloy, Melanie Ruzek and John M. Williams
Chapter 23 The Role of Alemtuzumab in Solid Organ Transplantation (pages 346โ361): Avinash Agarwal, David Bruno and Stuart J. Knechtle
Chapter 24 Rituximab, an Anti?CD20 Monoclonal Antibody (pages 362โ377): Mark D. Pescovitz
Chapter 25 The Anti?Interleukin 2 Receptor Antibodies (pages 378โ384): Muna Alnimri and Flavio Vincenti
Chapter 26 Infliximab/Anti?TNF (pages 385โ398): Marina Vardanyan, Edward C. Parkin and Horacio L. Rodriguez Rilo
Chapter 27 CTLA4?Ig (pages 399โ406): Sarah E. Yost and Bruce Kaplan
Chapter 28 Combination and Adjuvant Therapies to Facilitate the Efficacy of Costimulatory Blockade (pages 407โ428): Swetha K. Srinivasan, Helen L. Triemer and Allan D. Kirk
Chapter 29 Intravenous Immunoglobulin (IVIG) a Modulator of Immunity and Inflammation with Applications in Solid Organ Transplantation (pages 429โ445): Stanley C. Jordan, Mieko Toyoda, Joseph Kahwaji, Alice Peng and Ashley A. Vo