Conformationally restricted analogues of the antibacterial agent trimethoprim (TMP) were designed to mimic the conformation of drug observed in its complex with bacterial dihydrofolate reductase (DHFR). This conformation of TMP was achieved by linking the 4-amino function to the methylene group by o
β¦ LIBER β¦
Immunosuppressive Powers of the Antibacterial Agent Trimethoprim
β Scribed by GHILCHIK, MARGARET W.; MORRIS, A. S.; REEVES, D. S.
- Book ID
- 109674503
- Publisher
- Nature Publishing Group
- Year
- 1970
- Tongue
- English
- Weight
- 233 KB
- Volume
- 227
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/227393a0
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