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Immunosuppressive activities of 6(5h)-phenanthridinone, a new poly(adp-ribose)polymerase inhibitor

✍ Scribed by D. Weltin; V. Picard; K. Aupeix; M. Varin; D. Oth; J. Marchal; P. Dufour; P. Bischoff


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
489 KB
Volume
17
Category
Article
ISSN
0192-0561

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Effect of a poly(ADP-ribose) polymerase
✍ LuΓ­sa CristΓ³vΓ£o; JosΓ© Rueff πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 695 KB

The activity of poly(ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents. In the present work we evaluate the