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Immunosuppresive boronic acid dipeptides: correlation between conformation and activity

✍ Scribed by Kelly, Terence A.; Adams, Julian; Bachovchin, William W.; Barton, Randall W.; Campbell, Scot J.; Coutts, Simon J.; Kennedy, Charles A.; Snow, Roger J.


Book ID
126565550
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
257 KB
Volume
115
Category
Article
ISSN
0002-7863

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A series of trans-4,5-disubstituted-y-buty~iactones are found to adopt different conformations by aH NMR spectroscopy, whose optical rotation signs are found to depend on the conformations they assume. An empirical correlation rule is proposed for the prediction of optical activity and stereochemist