Immunostimulatory and anti-tumor activity of a water-soluble polysaccharide fromPhellinus baumiimycelia

Improvement of dissolution and oral abso

Improvement of dissolution and oral absorption of ER-34122, a poorly water-soluble dual 5-lipoxygenase/cyclooxygenase inhibitor with anti-inflammatory activity by preparing solid dispersion

✍ Ikuo Kushida; Masaki Ichikawa; Naoki Asakawa 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB

Several formulation approaches were attempted to improve the dissolution and the oral absorption of ER-34122, which is a novel dual 5-lipoxygenase/ cyclooxygenase inhibitor with potent anti-in¯ammatory activity. The solid dispersion of ER-34122 with hydroxypropylmethylcellulose (TC-5RW), which is an