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Immunoselection in vitro of a non-metastatic variant from a highly metastatic tumor

✍ Scribed by Philip Frost; Robert S. Kerbel

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
438 KB
Volume
27
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Immunoselection of a non‐metastatic variant of the highly metastatic MDAY‐D2 tumor of DBA/2 mice was achieved by means of an antiserum directed to the LY6.2 surface marker of MDAY‐D2. While the new tumor (MDAY‐D2.L61) expresses no detectable LY6.2, other measurable surface markers including H2^d^, FcR and TAA remain unchanged. The phenotypic behavior of MDAY‐D2.L61 is that of a non‐metastatic tumor and has remained stable after 1 year of maintenance in vivo and in vitro. Immunoselection can now be used to derive variants with stable phenotypic behavior from heterogeneous parent tumor cell populations.

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