## Abstract Previous reports from our group indicated that the MHC class I phenotype of metastatic lung colonies produced by a mouse fibrosarcoma tumor clone (B9) were, depending on the immune status of the host, MHC class I negative in immunocompetent mice and MHC class I positive in immunodeficie
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Immunoselection by T lymphocytes generates repeated MHC class I-deficient metastatic tumor variants
โ Scribed by Angel Garcia-Lora; Ignacio Algarra; Jose J. Gaforio; Francisco Ruiz-Cabello; Federico Garrido
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 372 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0020-7136
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Antibody-conjugated MHC class I tetramer
Antibody-conjugated MHC class I tetramers can target tumor cells for specific lysis by T lymphocytes
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Bruno Robert; Philippe Guillaume; Immanuel Luescher; Pedro Romero; Jean-Pierre M
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โ 114 KB
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To demonstrate that antibody-guided targeting of antigenic MHC class I-peptide tetramer on tumor cells can render them susceptible to lysis by relevant cytotoxic T lymphocytes (CTL), biotinylated HLA-A\*0201/Flu matrix peptide complexes were tetramerized on streptavidin molecules previously coupled