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Immunoregulatory T cells: Role and potential as a target in malignancy

✍ Scribed by Marc Beyer; Joachim L. Schultze

Book ID
107546586
Publisher
Current Science Inc.
Year
2008
Tongue
English
Weight
169 KB
Volume
10
Category
Article
ISSN
1523-3790

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We have further characterized the in vitro phenotype and function of anergic and suppressive CD4(+)25(+) T cells. Following TCR ligation, DO.11.10 CD4(+)25(+) T cells suppress the activation of OT-1 CD8(+)25(-) T cells in an antigen nonspecific manner. Although suppression was seen when using a mixt