𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Immunoreactivity of nerve lipid antigens in leprosy

✍ Scribed by Nalini Vemuri; Dr. Rama Mukherjee

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
412 KB
Volume
5
Category
Article
ISSN
0887-8013

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✦ Synopsis

Neural lipid antigens, namely, galactocerebroside and ganglioside, have been implicated in demyelinating diseases. We were interested in finding the role of these antigens in leprosy neuritis. The hurnoral immune response to these lipid antigens was quantitated by enzyme-linked immunosorbent assay in sera from 91 leprosy patients and 18 normal individuals. Our data revealed the presence of antibodies to total nerve lipids (TNL) and galactocerebroside (GalC) and a significantly low level to ganglioside (Gg) in all the categories of leprosy. No antilipid antibodies were detected in normals. Anti-TNL and anti-GalC antibodies were highest in tuberculoid leprosy patients. Statistically significant positive correlation was observed between anti-TNL and anti-GalC antibodies in lepromatous borderline, tuberculoid, and neuritic patients.

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