Immunoreactivity for p27KIP1 and cyclin E is an independent predictor of survival in primary gastric non-Hodgkin's lymphoma

✍ Scribed by Andrés J.M. Ferreri; Maurilio Ponzoni; Giancarlo Pruneri; Massimo Freschi; Roberta Rossi; Stefania Dell'Oro; Luca Baldini; Roberto Buffa; Nadia Carboni; Eugenio Villa; Giuseppe Viale

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: French
• Weight: 356 KB
• Volume: 94
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.1509

✦ Synopsis

Our aim was to assess the prognostic implications of the expression of p27 KIP1 and cyclin E in gastric lymphoma. We investigated the prognostic value of the immunoreactivity of these molecules in 92 cases of primary gastric lymphoma: 34

LGMLs, 24 DLCLMLs and 34 DLCLs. p27 was positive in 88% of LGMLs, 71% of DLCLMLs and 32% of DLCLs (p ‫؍‬ 0.004); cyclin E was positive in 9%, 33% and 59% of cases, respectively (p < 0.00001). p27/cyclin E immunoreactivity significantly correlated with histologic category, stage and LDH serum level. p27 immunoreactivity was significantly associated with better survival, whereas cyclin E reactivity was significantly related to worse outcome. Five-year CSS was 94% for patients with p27 ؉ /cyclin E -phenotype (n ‫؍‬ 42), 79% for p27 ؉ / cyclin E ؉ (n ‫؍‬ 14) or p27 -/cyclin E -(n ‫؍‬ 16) phenotype and 60% for p27 -/cyclin E ؉ phenotype (n ‫؍‬ 16) (p ‫؍‬ 0.02). The prognostic role of p27/cyclin E expression was confirmed when analyzed separately within LGMLs and large-cell lymphomas. Immunoreactivity for p27 and cyclin E is an independent predictor of survival in PGLs that may be an adjunctive tool in identifying high-risk patients. It correlates with histologic category, stage and LDH serum level. p27 -/cyclin E ؉ phenotype is associated with worse survival, probably due to a synergistic effect of both cell-cycle defects. The predictive role of these molecules within each histologic group of PGLs deserves to be confirmed in larger series.