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Immunoreactivity against goblet cells in patients with inflammatory bowel disease

✍ Scribed by Brita Ardesjö; Guida M. Portela-Gomes; Fredrik Rorsman; Eva Gerdin; Lars Lööf; Lars Grimelius; Olle Kämpe; Olov Ekwall

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
440 KB
Volume
14
Category
Article
ISSN
1078-0998

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✦ Synopsis

Background: A number of autoantibodies have been reported in inflammatory bowel disease (IBD). The aim of this study was to investigate to what extent sera from patients with IBD contain autoantibodies directed against normal human gastrointestinal mucosa.

Methods: Samples of sera from 50 patients with IBD and 50 healthy subjects were used for immunostaining of normal and affected human gastrointestinal tissues.

Results:

Eighty-four percent of the sera from IBD patients showed immunoreactivity against goblet cells in the appendix compared with 8% of the sera from healthy subjects. Goblet cell reactivity of IBD patient sera varied between regions in the gastrointestinal tract. Sera from healthy subjects only reacted with goblet cells in the appendix. In the colon and the appendix, goblet cell reactivity of IBD sera was generally weak at the base of the crypts and gradually increased toward the lumen. Three IBD sera samples reacted with gastrin cells in the antrum. In colon biopsies from patients with ulcerative colitis, immunoreactivity against the remaining goblet cells showed an inverse correlation with inflammatory activity.

Conclusions:

These findings suggest that immunoreactivity against goblet cells may be of central importance in the pathogenesis of IBD. Identification of goblet cell antigens could lead to a better understanding of IBD and provide a new diagnostic tool.

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