Immunophenotyping specimens from HIV-infected persons: Laboratory guidelines from the Centers for Disease Control and Prevention
✍ Scribed by Dr. Janet K. A. Nicholson
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 472 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0196-4763
No coin nor oath required. For personal study only.
✦ Synopsis
In January 1993, the Centers for Disease Control and Prevention (CDC) revised its AIDS Classification System to include a low CD4 + T-cell count as a criterion for the diagnosis of the acquired immunodeficiency syndrome (AIDS) (1). This revision was the end result of a 2-year effort to include laboratory criteria for assessing immunosuppression, which is characteristic of severe HIV infection. Among the concerns raised in the process of revising the classification system was the variability in CD4 determinations, both for replicate measures and for measures made in different labs. If certain CD4 + T-cell levels are deemed to be clinically relevant, then it is imperative that a CD4 + result of 200 or 500 cells/kl be the same in '