Immunophenotyping of lymphocyte T and B in the peripheral blood of systemic lupus erythematosus
β Scribed by Shaoxian, Hu ;Deding, Tao ;Peigen, He
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 190 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0257-716X
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π SIMILAR VOLUMES
## Abstract ## Objective To gain preliminary evidence for the safety and efficacy of B lymphocyte depletion therapy in refractory systemic lupus erythematosus (SLE). ## Methods Six female patients with active SLE, resistant to standard immunosuppressive therapy, were treated on an openβlabel bas
Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.