Immunoperoxidase characterization of extramedullary plasmacytoma of the head and neck

✍ Scribed by Mock, Presley M. ;Neal, G. David ;Aufdemorte, Thomas B.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1987
• Weight: 501 KB
• Volume: 9
• Category: Article
• ISSN: 0148-6403
• DOI: 10.1002/hed.2890090610

✦ Synopsis

A retrospective analysis of 18 cases of extramedulary plasmacytoma (EMP) was done to characterize the type of immunoglobulin being synthesized by the neoplastic cells. The immunoperoxidase stain can be performed on previously fixed tissue and offers a means of predicting the likelihood of progression to multiple myeloma (MM). Tumors producing IgG make up the majority of cases of EMP in the literature and only 9% have progressed to MM. Smaller numbers of tumors producing other immunoglobulin classes have been studied, but it is clear that their prognosis is much more grave. HEAD 81 NECK SURGERY 9~356-361,1987

Extramedullary plasmacytomas (EMP) are uncommon neoplasms of B-lymphocyte populations occurring most commonly in the head and neck.' The relationship between EMP, multiple myeloma (MM), and solitary osseous plasmacytoma (SOP) is poorly understood and continues to be a controversial issue.'^ Batsakis' favors the hypothesis that EMP demonstrates a behavior pattern more similar to lymphoreticular neoplasms than MM. However, Kapodia et al.4

conclude from

From the Division of Otorhinolaryngology (Drs Mock and Neal) and the