Immunomodulatory effects of treatment with naproxen in patients with rheumatic disease

✍ Scribed by Dr. Jan L. Ceuppens; Geert Robaeys; Wilfried Verdickt; Simonne Vertessen; Hans Deckmyn; Jan Dequeker

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 668 KB
• Volume: 29
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780290301

✦ Synopsis

We evaluated the effects of a nonsteroidal antiinflammatory drug, naproxen, on phytohemagglutinin (PHA)-induced lymphocyte proliferation. When added in vitro to cultures of peripheral blood mononuclear cells, naproxen enhanced the proliferative response toward PHA of lymphocytes from rheumatoid arthritis (RA) patients but not from healthy volunteers, and it reduced prostaglandin E2 (PGE2) synthesis in the cultures. Oral treatment for 7 days with naproxen also resulted in a significant enhancement of the in vitro PHA-induced proliferation of lymphocytes from RA patients and from age-matched control patients with noninflammatory rheumatic diseases, but not from young healthy controls. This enhancement of PHAinduced lymphocyte proliferation after oral intake of naproxen was not accompanied by diminished in vitro PGEz production in the cultures. It did occur when PGE2-producing monocytes were removed and when in vitro PGE2 synthesis was blocked with indomethacin.