Immunomodulatory Effects of IFN-β and Lovastatin on Immunophenotype of Monocyte-Derived Dendritic Cells in Multiple Sclerosis

Double-stranded secondary structures on

Double-stranded secondary structures on mRNA induce type I interferon (IFN α/β) production and maturation of mRNA-transfected monocyte-derived dendritic cells

✍ M. Ceppi; N. Ruggli; V. Tache; H. Gerber; K. C. McCullough; A. Summerfield 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 985 KB

## Abstract ## Background The development of dendritic cell (DC)‐based vaccines using antigen‐encoding mRNA requires identification of the critical parameters for efficient __ex vivo__ loading of DCs. Exogenously delivered mRNA can induce DC activation, but the molecular mechanisms involved are un