Immunomodulatory and therapeutic properties of FK-565 in mice

✍ Scribed by James E. Talmadge; Barbara Lenz; Mark Schneider; Hamblin Phillips; Cedric Long

• Book ID: 104660382
• Publisher: Springer-Verlag
• Year: 1989
• Tongue: English
• Weight: 915 KB
• Volume: 28
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00199108

✦ Synopsis

The heptanoyl tripeptide, FK-565 is a biological response modifier with potent therapeutic properties for the treatment of experimental and spontaneous metastases. Doses of FK-565 greater than 5 mg/kg are required for in vivo augmentation of natural killer cells, macrophages, and for therapeutic activity, presumably because FK-565 is a peptide small molecular mass which is rapidly degraded and excreted. Optimal therapeutic activity is observed at approximately 2 5 -5 0 m g / k g FK-565, administered i.v. three times per week for 4 weeks. In addition to its therapeutic properties, which were consistently greater than the positive control at optimal doses, FK-565 had significant immunoaugmentary properties for natural killer cells, macrophages, and T cells both in vitro and in vivo, suggesting that its therapeutic activity is due to immune augmentation.