Our earlier investigation demonstrated that methoxychlor treatment induced hepatic cytochrome P450 2B1/2B2 and 3A proteins in rats and enhanced their respective enzymatic activities. To determine the mechanism of the methoxychlor-mediated induction and whether methoxychlor acts as a frank inducer an
Immunomodulation by 2'deoxyguanosine and the induction of experimental hepatitis in the rat
โ Scribed by W.W. Bakker; A. Hermelink; H.J. Houthoff
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 84 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0192-0561
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The blood kinetics of carbaryl were followed over 24 h after oral administration of 14C-carbaryl at 20 mg k g (0.17pCimg-') in control animals and in animals with an altered liver function (70% hepatectomy or tranylcypromine treatment). The variations in the primary toxicity of carbaryl were assesse