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Immunomodulating Steroidal Glycosides from the Roots of Stephanotis mucronata

✍ Scribed by Yiping Ye; Xiaoyu Li; Hongxiang Sun; Fengyang Chen; Yuanjian Pan

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
112 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Guided by in vitro immunological tests, three immunomodulating steroidal glycosides, stemucronatosides A (1), B (2), and C (3), were isolated from the roots of Stephanotis mucronata. On the basis of chemical evidence and extensive spectroscopic methods including 1D and 2D NMR, their structures were determined as 12‐O‐deacetylmetaplexigenin 3‐[O‐6‐deoxy‐3‐O‐methyl‐β‐D‐allopyranosyl‐(1→4)‐O‐β‐D‐cymaropyranosyl‐(1→4)‐β‐D‐cymaropyranoside], 12‐O‐deacetylmetaplexigenin 3‐[O‐β‐D‐thevetopyranosyl‐(1→4)‐O‐β‐D‐cymaropyranosyl‐(1→4)‐β‐D‐cymaropyranoside], and metaplexigenin 3‐[O‐β‐D‐glucopyranosyl‐(1→4)‐O‐6‐deoxy‐3‐O‐methyl‐β‐D‐allopyranosyl‐(1→4)‐O‐β‐D‐cymaropyranosyl‐(1→4)‐β‐D‐cymaropyranoside], respectively. These compounds showed immunomodulating activities in vitro.

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