Title page
Copyright page
Contents
Preface
Acknowledgements
Note on the tenth edition
How to use this book
Further reading
List of abbreviations
Immunity
1: The scope of immunology
2: Innate and adaptive immune mechanisms
Innate immunity
Adaptive immunity
Interactions between innate and adaptive immunity
3: Recognition and receptors: the keys to immunity
Innate immune system
Soluble recognition molecules
Cell-associated recognition
Some other receptor systems
Adaptive immune system
4: Cells involved in immunity: the haemopoietic system
A note on terminology
Innate immunity
5: Receptors of the innate immune system
6: Complement
Classic pathway
Alternative pathway
MBL and other pathways
Lytic pathway
Complement inhibitors
7: Acute inflammation
8: Phagocytic cells and the reticuloendothelial system
9: Phagocytosis
Adaptive immunity
(i) The molecular basis
10: Evolution of recognition molecules: the immunoglobulin superfamily
Adaptive immunity
11: The major histocompatibility complex
12: The T-cell receptor
13: Antibody diversification and synthesis
14: Antibody structure and function
(ii) The cellular basis
15: Lymphocytes
16: Primary lymphoid organs and lymphopoiesis
Yolk sac
Bursa
Liver
Bone marrow
Thymus
17: Secondary lymphoid organs and lymphocyte traffic
Lymph node
Spleen
Mucosa-associated lymphoid tissues
(iii) The adaptive immune response
18: Antigen processing and presentation
The class I pathway
The class II pathway
19: The antibody response
20: Antigen β antibody interaction and immune complexes
Antigen β antibody interaction
Immune complexes
21: Cell-mediated immune responses
(iv) Regulation
22: Tolerance
23: Cell communication and cytokines
24: The cytokine network
25: Immunity, hormones and the brain
Central nervous system
Autonomic nervous system
Endocrine system
Immune system
Immunity and psychological illness
Potentially useful immunity
26: Antimicrobial immunity: a general scheme
27: Immunity to viruses
Viruses
Atypical organisms
28: HIV and AIDS
29: Immunity to bacteria
Bacteria
30: Immunity to fungi and ectoparasites
Ectoparasites
31: Immunity to protozoa
32: Immunity to worms
Roundworms (nematodes)
Flukes (trematodes)
Tapeworms (cestodes)
Undesirable effects of immunity
33: Immunodeficiency
Defects affecting several types of cell
Defects predominantly affecting T cells
Defects predominantly affecting B cells
Defects of complement
Defects affecting myeloid cells
Receptors of innate immunity
Secondary immunodeficiency
34: Harmful immunity: a general scheme
Innate immune damage
Types of hypersensitivity (Gell and Coombsβ classification)
35: Allergy and anaphylaxis
Mediators
Inhibitors
Non-IgE triggering
Allergic diseases
36: Immune complexes, complement and disease
Immune complex diseases
Haemolytic disease of the newborn
37: Chronic and cell-mediated inflammation
Granulomas
Granulomatous diseases
38: Autoimmune disease
Self-tolerance and self-reactivity
Autoimmune diseases
Treatment of autoimmunity
Altered immunity
39: Transplant rejection
Typing and matching
Rejection
Immunosuppression (for further details see Fig. 40)
40: Immunosuppression
Non-specific immunosuppression
Specific immunosuppression
41: Immunostimulation and vaccination
Passive immunization
Active immunization (βvaccinationβ)
Immunity in health and disease
42: Cancer immunology
Non-specific immunotherapy
Specific immunotherapy
43: Immunity and clinical medicine
44: Investigating immunity
Investigating immunodeficiency (see also Fig. 33)
Investigating allergy (see also Fig. 35)
Investigating autoimmunity (see also Fig. 38)
Tissue typing and transplantation (see also Fig. 39)
Tumours of immunological cells
45: Immunology in the laboratory
46: Out of the past: evolution of immune mechanisms
Unicellular organisms
Invertebrates
Vertebrates
Plants
47: Into the future: immunology in the age of genomics
Self-assessment
Self-assessment questions
Answers
Appendices
Appendix I
Comparative sizes
Comparative molecular weights
Appendix II
Landmarks in the history of immunology
Some unsolved problems
Appendix III
CD classification
Index
