𝔖 Bobbio Scriptorium
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Immunological tailoring of monoclonal antibodies for immunotherapy of pancreatic carcinoma

✍ Scribed by K. Bosslet; N. Döring; G. Seemann; G. Schulz; H. H. Sedlacek

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
342 KB
Volume
41
Category
Article
ISSN
0020-7136

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✦ Synopsis

Spontaneous isotype switch variants from lgGl to I&, of monoclonal antibody (MAb) BW 494 were generated. Their frequency was found to be I variant cell out of 2 x lo5 parental hybrid cells. The tissue specificity of the parental MAb BW 494 IgGI was identical to that of the BW 494 IgG2, variant arguing for an unaltered paratope shared by the parent and the variant. In contrast, the switch in isotype from lgGl to lgGla resulted in an increase of the variant potential to mediate antibody dependent cellular cytotoxicity (ADCC) reaction with human peripheral blood mononuclear cells as effectors. The potential of variants to perform human complement mediated cytolysis (CDC) was not better than that of the parental MAb.

MAb BW 494 of IgG1-isotype binds to a carbohydrate epitope located on a high molecular weight glycoprotein associated with pancreatic, colorectal and stomach carcinomas (Bosslet et al. , 1986~). Immunoscintigraphic studies

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