𝔖 Bobbio Scriptorium
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Immunological studies in childhood scleroderma

✍ Scribed by W. Stögmann; M. Sandhofer; J. Fritz

Publisher
Springer
Year
1977
Tongue
English
Weight
407 KB
Volume
124
Category
Article
ISSN
0340-6997

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✦ Synopsis

The results of immunological studies on 13 children suffering from scleroderma are reported. Antinuclear antibodies with speckled pattern of fluorescence could be found in systemic sclerosis and in 3 patients with scleroderma en bandes. The same patients (except but one with PSS) demonstrated high levels of DNA antibodies. The 2 patients with PSS were found to have a very low percentage of T cells, whereas the percentage of B cells was increased.

The results demonstrate the significance of autoimmunity not only in systemic sclerosis but also in focal scleroderma. Beyond this it can be presumed that immune deficiency (with a defect in cellular immunity) may be the predisposing cause of at least progressive systemic sclerosis.

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