Immunological evaluation of the alcohol-soluble protein fraction from gluten-free grains in relation to celiac disease
✍ Scribed by Paolo Bergamo; Francesco Maurano; Giuseppe Mazzarella; Gaetano Iaquinto; Immacolata Vocca; Anna Rita Rivelli; Enrica De Falco; Carmen Gianfrani; Mauro Rossi
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 180 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1613-4125
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✦ Synopsis
Abstract
Celiac disease (CD) is a gluten‐sensitive enteropathy with an immune basis. We established the immune reactivity of the alcohol‐soluble fraction from two minor cereals (tef and millet) and two pseudocereals (amaranth and quinoa) which are believed to be nontoxic based on taxonomy. Grains were examined in intestinal T‐cell lines (iTCLs), cultures of duodenal explants from HLA‐DQ2^+^ CD patients and HLA‐DQ8 transgenic mice for signs of activation. Our data indicated that tef, millet, amaranth, and quinoa did not show any immune cross‐reactivity toward wheat gliadin, and therefore confirming their safety in the diet of CD patients.