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Immunological Efficacy of hsp60 Peptide DiaPep277 Therapy in Human Type 1 Diabetes

✍ Scribed by Bart Roep

Book ID
113539697
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
53 KB
Volume
123
Category
Article
ISSN
1090-2341

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## Abstract ## Background Type 1 diabetes results from a T‐cell mediated autoimmune destruction of insulin‐producing pancreatic beta‐cells. The 60‐kDa heat‐shock protein (hsp60) is one of the known target self‐antigens. An immunogenic peptide from hsp60, p277, arrested beta‐cell destruction and ma

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## Abstract ## Background Aim of this trial was to test whether heat shock protein peptide DiaPep277 treatment in adult and paediatric patients with recent‐onset type 1 diabetes (T1D) is safe and whether it can preserve endogenous insulin production. ## Methods Two studies were performed in a pr