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Immunological diagnosis of multiple myeloma in a medieval bone

✍ Scribed by C. Cattaneo; K. Gelsthorpe; P. Phillips; T. Waldron; J. R. Booth; Dr R. J. Sokol

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
138 KB
Volume
4
Category
Article
ISSN
1047-482X

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✦ Synopsis

An inhibition enzyme-linked immunosorbent assay using monoclonal antibodies has been used to confirm the diagnosis of IgA type multiple myeloma in a small fragment (< 10 g) of cranium from a medieval female. Further testing by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and immunoblotting showed that the IgA was mainly polymeric, suggesting that the individual would have suffered from a hyperviscosity syndrome. This is the first time that immunological assays have been used to diagnose multiple myeloma in ancient human tissue and have permitted speculation on associated clinical symptoms.

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