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Immunological detection of glutamate receptor subtypes in human central nervous system

✍ Scribed by Craig D. Blackstone; Allan I. Levey; Lee J. Martin; Donald L. Price; Dr Richard L. Huganir

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 661 KB
Volume: 31
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410310620

No coin nor oath required. For personal study only.

✦ Synopsis

Glutamate receptors are the principal excitatory neurotransmitter receptors in the central nervous system and are involved in a number of normal and pathological neuronal processes. Using subunit-specific antipeptide antibodies developed against the predicted amino acid sequences of several rat glutamate receptor cDNAs, we have identified these proteins in post-mortem human central nervous system tissue. Immunoblotting of dissected brain regions demonstrates that these receptor proteins are differentially distributed. The ability to identify these proteins in post-mortem human tissues should allow examination of the changes in levels of receptor subtypes that occur in a variety of neurological and psychiatric diseases.

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