Immunologic sex differences and the female predominance in systemic lupus erythematosus
β Scribed by Dr. Robert D. Inman
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 370 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0004-3591
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β¦ Synopsis
Abstract
The female predominance in many rheumatic disorders, most notably systemic lupus erythematosus, suggests that immunologic sex differences may modify susceptibility to disease. Clinical and experimental data indicate heightened humoral immunity and depressed cellular immunity in females compared with males. These differences appear to be mediated by sex hormones.
π SIMILAR VOLUMES
## Abstract This report describes a patient with active systemic lupus erythematosus (SLE) who evidenced severe bleeding consequent to a profound and isolated reduction in plasma factor II (prothrombin) activity. Absence of the factor is documented by immunologic means and its return after corticos