𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Immunologic features of a carcinogen-induced murine bladder cancer: In vivo and in vitro studies

✍ Scribed by Dr. N. Javadpour; C. L. Hyatt; T. Soares

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
314 KB
Volume
11
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Certain in vivo and in vitro immunologic features of carcinogen‐induced murine bladder cancer have been studied. The consistency of tumor induction, its natural history, and immunogenicity both in vivo and in vitro render this syngeneic murine bladder tumor a suitable model for immunologic studies. Pre‐immunization of strain C3H/Hen mice with mid‐gestational fetal cells did not protect the animals from tumor challenge. Sera of mice immunized with mid‐gestational fetal cells were not cytotoxic to cultured tumor cells in a microcytotoxicity assay indicative of dissimilarity between the tumor associated antigen and the syngeneic mid‐gestational fetal antigen.

📜 SIMILAR VOLUMES

Anti-neoplastic activity of paclitaxel o
Anti-neoplastic activity of paclitaxel on experimental superficial bladder cancer: In vivo and in vitro studies
✍ Ofer Nativ; Moshe Aronson; Ora Medalia; Tatiana Moldavsky; Edmond Sabo; Israel R 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 84 KB 👁 2 views

The effects of intravesical administration of paclitaxel (taxol) in a bladder tumor model in mice, as well as the drug's in vitro activity on the same tumor cells, have been studied. Two cell lines, derived from MBT-2 cells, were employed in these experiments. The T50 line (obtained by many passages

Overexpression of bcl-2 regulates sodium
Overexpression of bcl-2 regulates sodium butyrate- and/or docetaxel-induced apoptosis in human bladder cancer cells both in vitro and in vivo
✍ Hideaki Miyake; Shoji Hara; Soichi Arakawa; Sadao Kamidono; Isao Hara 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 188 KB 👁 1 views

Sodium butyrate (NaBt), a physiologically occurring shortchain fatty acid, induces differentiation as well as apoptosis in numerous cell types, and this induction is partially regulated by Bcl-2 expression. The objectives of our study were to characterize the in vitro effects of NaBt and/or docetaxe

TP53 alterations and patterns of carcino
TP53 alterations and patterns of carcinogen exposure in a U.S. population-based study of bladder cancer
✍ Karl T. Kelsey; Tomoko Hirao; Shuya Hirao; Tara Devi-Ashok; Heather H. Nelson; A 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 101 KB

## Abstract The molecular pathology of bladder cancer has been the subject of considerable interest, and current efforts are targeted toward elucidating the interrelationships between individual somatic gene loss and both etiologic and prognostic factors. Mutation of the __TP53__ gene has been asso

Efficacy of transfection rates on head a
Efficacy of transfection rates on head and neck squamous cell cancer by a novel adenovirus: An in vivo and in vitro study
✍ Elise S. Lalonde; Gregory Beyer; Paul L. Friedlander; Jay K. Kolls 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB

## Abstract ## Introduction Internalization of wild‐type adenovirus is dependent on binding to a coxsackie‐adenovirus receptor (CAR). Unfortunately, many tumors lack these receptors. We hypothesized that a novel RGD adenovirus, which binds by way of cellular integrins, would improve the transfecti