Recent developments in the genetics and molecular A fundamental step in the pathogenesis of spongibiology of spongiform encephalopathies (prion disform encephalopathies (prion diseases) is the convereases) confirm the key role of prion protein (PrP Sc ) 2 in sion of the cellular isoform of prion pro
Immunolocalization of the cellular prion protein in normal brain
✍ Scribed by Kenneth L. Moya; Nicole Salès; Raymonde Hässig; Christophe Créminon; Jacques Grassi; Luigi Di Giamberardino
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 567 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1059-910X
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## Abstract Prion diseases are characterized by high accumulation of infectious prion proteins (PrP^Sc^) in brains. PrP^Sc^ are propagated by the conversion of host‐encoded cellular prion proteins (PrP^C^) which are essential for developing the disease but are heterogeneously expressed in brains. T
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