Immunolocalization of MMP-19 in the human intervertebral disc: implications for disc aging and degeneration
β Scribed by Gruber, HE; Ingram, JA; Hanley, EN
- Book ID
- 120627791
- Publisher
- Informa plc
- Year
- 2005
- Tongue
- English
- Weight
- 264 KB
- Volume
- 80
- Category
- Article
- ISSN
- 1052-0295
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## Abstract A significant biochemical change that takes place in intervertebral disc degeneration is the loss of proteoglycans in the nucleus pulposus. Proteoglycans attract fluid, which works to reduce mechanical stresses in the solid matrix of the nucleus and provide a hydrostatic pressure to the
Proteoglycans (PGs) purified from 19-year-old male (19M), 53-year-old female (53F), and 15-16-year-old adolescent idiopathic scoliotic (AIS) disc tissues were characterised by their aggregation properties with hyaluronic acid (HA), glycosaminoglycan (GAG), and amino acid composition, electrophoretic