The c-met proto-oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF), a potent mitogen and motogen for epithelial cells. Because of its profound effects on cell growth and motility, HGF may be important in the development of cancer metastases in hepatocellular carcinoma (
Immunolocalization of hepatocyte growth factor and its receptor (c-Met) during mouse liver development
โ Scribed by Kiyoshi S. Ishikawa; Tohru Masui; Katsutoshi Ishikawa; Nobuyoshi Shiojiri
- Book ID
- 106099388
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 718 KB
- Volume
- 116
- Category
- Article
- ISSN
- 1432-119X
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mal and malignant epithelial cells and several other cell The c-met proto-oncogene encodes the tyrosine kinase types, including endothelial cells and melanocytes. 4,5 receptor for hepatocyte growth factor (HGF), a potent It has been reported that the expression of c-Met is enmitogen and motogen for
cases of well-differentiated hepatocellular carcinoma (HCC) (grades I-
Hepatocyte growth factor (HGF) and its receptor c-met are present in several human tissues but their expression in mesothelial cells has not been examined. In this study, we have investigated the expression of HGF and c-met in normal human mesothelial cells and 11 human malignant mesothelioma cell l