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Immunolocalization of desmoglein and intermediate filaments in human oral squamous cell carcinomas

✍ Scribed by Dr. Kazushi Imai; Dr. Shigehiro Kumagai; Dr. Kiyomasa Nakagawa; Dr. Etsuhide Yamamoto; Dr. Isao Nakanishi; Dr. Yasunori Okada

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
981 KB
Volume
17
Category
Article
ISSN
1043-3074

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✦ Synopsis

Background. Information is limited as to how to predict the malignant behavior of the oral squamous cell carcinomas. The invasive and metastatic phenotype of the carcinoma cells may be related to changes in the expression of desmo-soma1 and cytoskeletal proteins.

Methods. To investigate the expression of desmoglein, cytokeratins, and vimentin, 22 biopsy specimens of oral squamous cell carcinomas were examined by immunohistochemistry. The data were analyzed by morphometry with reference to the cell differentiation, mode of invasion, and cervical lymph node metastasis.

Results. The expression of desmoglein, a major desmo-soma1 glycoprotein, was remarkably reduced in the poorly differentiated, highly invasive, and metastatic carcinomas. Although the immunohistochemical expression of cytokeratins in the carcinoma cells was a good marker for the differentiation status of the carcinomas, the level of expression From the Departments of Pathology (Drs Imai. Nakanishi, and Okada) and Oral and Maxillo-

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