𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Immunohistochemical study of the expression of human chorionic gonadotropin-β in oral squamous cell carcinoma

✍ Scribed by Kanokporn Bhalang; Abdel H. Kafrawy; Dale A. Miles

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
397 KB
Volume
85
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Human chorionic gonadotropin (hCG) is a glycoprotein hormone comprised of two dissimilar subunits (␣ and ␤) and normally is synthesized by trophoblastic tissue. Although hCG expression has been identified in a variety of neoplastic tissues, to the authors' knowledge no investigation has centered on tumors of oral origin.

METHODS.

Oral squamous cell carcinomas (OSCC) were studied in comparison with oral fibromas for the presence of hCG␤ using the avidin-biotin-peroxidase complex immunohistochemical technique.

Results

. hCG␤ immunoreactivity was identified in 29 of 45 OSCC (64%). The positively staining cells in each tumor specimen were few (range, 0.5-5%) and were scattered throughout the tumor. When tumors were classified according to grade, it was found that hCG␤ staining was positive in 5 of 15 well differentiated OSCC (33%), in 12 of 15 moderately differentiated OSCC (80%), and in 12 of 15 moderately to poorly differentiated OSCC (80%). hCG␤ immunoreactivity could not be demonstrated in any of the oral fibromas.

CONCLUSIONS.

The presence of hCG␤ positive tumor cells appears potentially to reflect a malignant behavior of OSCC.

📜 SIMILAR VOLUMES

Expression of the α- and β-subunits of h
Expression of the α- and β-subunits of human chorionic gonadotropin by subsets of parathyroid cells in states of hyperparathyroidism
✍ Carlinfante, Gabriele; Lampugnani, Rinaldo; Azzoni, Cinzia; Aprile, Maria Rosari 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB

The alpha-subunit of human chorionic gonadotropin (hCG-alpha) has previously been found to be expressed in hyperplasias and tumours of numerous endocrine tissues including all those involved in MEN-I syndrome except the parathyroid glands. In the present immunohistochemical investigation of 86 patie

Immunohistochemical study of chondroitin
Immunohistochemical study of chondroitin-6-sulphate and tenascin in the larynx: a loss of chondroitin-6-sulphate expression accompanies squamous cell carcinoma invasion
✍ Uhlman, Dorothy L.; Niehans, Gloria A. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB 👁 1 views

Chondroitin 6-sulphate is a glycosaminoglycan component of both cell membrane and basement membrane proteoglycans. In vitro it can inhibit tenascin, a molecule critical for epithelial cell migration during development and in wound healing. The immunohistochemical expression of chondroitin-6-sulphate

Functional characterization of p53 molec
Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck
✍ W. Andrew Yeudall; Judit Jakus; John F. Ensley; Keith C. Robbins 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 2 views

Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this

Clinicopathologic significance of lamini
Clinicopathologic significance of laminin-5 γ2 chain expression in squamous cell carcinoma of the tongue : Immunohistochemical analysis of 67 lesions
✍ Yukiko Ono; Yukihiro Nakanishi; Yoshinori Ino; Toshiro Niki; Tesshi Yamada; Kimi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 181 KB

BACKGROUND. The laminin-5 ␥2 chain plays an important role in cell migration during tumor invasion and tissue remodeling. METHODS. Laminin-5 ␥2 chain expression in squamous cell carcinomas of the tongue in 67 patients with Stage II, III, or IVA,B (excluding the cases with distant metastasis) was exa

Collagenase-3 expression is associated w
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx
✍ Cazorla, Maite; Hernández, Luis; Nadal, Alfons; Balbín, Milagros; López, José M. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB 👁 1 views

Collagenase-3 (MMP-13) is a matrix metalloproteinase recently identified on the basis of differential expression in normal breast tissues and in breast carcinoma. To date, collagenase-3 expression has been reported only in breast carcinomas and in articular cartilage of arthritic patients; the prese

DNA studies underestimate the major role
DNA studies underestimate the major role of CDKN2A inactivation in oral and oropharyngeal squamous cell carcinomas
✍ Chu Lee Wu; Luca Roz; Susan McKown; Philip Sloan; Andrew P. Read; Susan Holland; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 163 KB 👁 1 views

Loss of CDKN2A expression was demonstrated by immunohistochemistry in 87% of oral and oropharyngeal squamous cell carcinoma (OSCC) primary tumor samples. By contrast, DNA studies showed a much lower frequency of loss of the CDKN2A gene. Point mutations and promoter methylation of CDKN2A were seen in