Immunohistochemical staining for mismatch repair proteins, and its relevance in the diagnosis of hereditary non-polyposis colorectal cancer

Loss of DNA mismatch repair function and

Loss of DNA mismatch repair function and cancer predisposition in the mouse: Animal models for human hereditary nonpolyposis colorectal cancer

✍ Edelmann, Lisa ;Edelmann, Winfried 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 2 views

## Abstract Germline mutations in DNA mismatch repair genes underlie one of the most common hereditary cancer predisposition syndromes known in humans, hereditary nonpolyposis colorectal cancer (HNPCC). Defects of the DNA mismatch repair system are also prevalent in sporadic colorectal cancers. The