Immunohistochemical expression of cytokeratins in intrahepatic cholangiocarcinoma and metastatic adenocarcinoma of the liver

✍ Scribed by Sasaki, Atsushi; Kawano, Katsunori; Aramaki, Masanori; Nakashima, Kimihiro; Yoshida, Takanori; Kitano, Seigo

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 368 KB
• Volume: 70
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/(sici)1096-9098(199902)70:2<103::aid-jso8>3.0.co;2-h

✦ Synopsis

Background and Objectives: This study was designed to identify a difference in immunostaining that might help to distinguish between primary and metastatic liver neoplasms. Methods: We examined immunohistochemical expression of cytokeratins (CKs) 7, 8, 19, and 20 in 12 intrahepatic cholangiocarcinomas (ICCs; 9 of the mass-forming and 3 of the infiltrating type), 25 metastatic colorectal carcinomas (MCCs), and 7 metastatic gastric carcinomas (MGCs) of the liver. Results: CKs 7 and 19 were expressed in all ICCs of infiltrating type, while each was seen in 7/9 (77.8%) of mass-forming type. CK 7-positive/ CK 20-negative was seen in 9/12 (75.0%) of ICCs and in none of the 25 MCCs, while CK 7-negative/CK 20-positive was seen in 1/12 (8.3%) of ICCs and 20/25 (80.0%) of MCCs. No differences were observed between MGCs and ICCs. Conclusions: These results suggest that immunohistochemical staining for both CKs 7 and 20 is useful for the differential diagnosis of ICCs and MCCs, whereas phenotypic expression of CKs appears to be different between mass-forming and infiltrating types of ICCs.