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Immunohistochemical expression of COX-2 and c-kit in metastatic uveal melanoma

✍ Scribed by Frota, Ana C.A.; Odashiro, Alexandre N.; Pereira, Patricia R.; Fernandes, Bruno F.; Godeiro, Katyanne Dantas; Filho, Joao Pessoa Souza; Burnier Jr., Miguel N.


Book ID
123430465
Publisher
Canadian Ophthalmological Society
Year
2007
Tongue
English
Weight
133 KB
Volume
42
Category
Article
ISSN
0008-4182

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## Abstract Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Disease metastasis occurs in half of the patients and is uniformly fatal despite systemic therapy. Inducible nitric oxide synthase (iNOS) is associated with disease progression in various malignancies including

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HLA class I is expressed in 75-85 per cent of uveal melanoma and cytoplasmic c-myc expression has been reported in 78 per cent of uveal melanoma. In skin melanoma, an inverse relationship has been observed between HLA class I expression and c-myc. The purpose of this study was to determine whether a