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Immunohistochemical expression of bone morphogenetic protein-2 in pilomatricoma

✍ Scribed by I. Kurokawa; K. Kusumoto; K. Bessho; Y. Okubo; H. Senzaki; A. Tsubura

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
381 KB
Volume
143
Category
Article
ISSN
0007-0963

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✦ Synopsis

Background:

The mechanism of occurrence of calcification and ossification in pilomatricoma remains unclear.

Objectives:

To elucidate the pathogenesis of calcification and ossification in pilomatricoma we examined the role of bone morphogenetic protein (bmp)-2, which plays important parts in inducing ectopic bone formation both in vivo and in vitro.

Methods:

Twenty cases of pilomatricoma were studied immunohistochemically using anti-bmp-2 monoclonal antibody.

Results:

In normal skin, including hair follicles, there was no bmp-2 expression. in all pilomatricomas, bmp-2 was found exclusively in the cytoplasm of shadow cells but not in basophilic cells. in two cases of bone formation seen in pilomatricoma, osteoblasts in the periosteal area showed a strong positive reaction, while bone trabeculum (bone matrix) showed no reaction.

Conclusions:

Our findings indicate that shadow cells positive for bmp-2 may play an important part in generating bone formation in pilomatricoma.

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